Design and antiproliferative and antioxidant activities of furan-based thiosemicarbazides and 1,2,4-triazoles: their structure-activity relationship and SwissADME predictions

Due to the limited number of drugs in current clinical use, diverse biological applications furan have encouraged preparation a wide variety thiosemicarbazide and triazole derivatives for purpose developing new drug agents. This study aimed investigate antiproliferative antioxidant activities thiosemicarbazides (1–12) 1,2,4-triazoles (13–24). Out synthesized target compounds, 3, 4, 6, 7, 8, 9, 10, 11, 12, 15, 16, 18, 19, 20, 21, 22, 23, 24 are novel while synthesis remaining compounds is present literature. Compound 15 (IC50: 8.81 ± 0.28 µM) showed highest activity against cervical (HeLa) cancer cell line among compounds. In lipid peroxidation inhibitory activity, 9 with IC50 21.80 0.69, 26.49 0.61, 29.07 0.52 µM, respectively, 22 exhibited activity. Moreover, physicochemical properties, pharmacokinetic drug-likeness all products were calculated using SwissADME. addition, effect structure–activity relationships 1,2,4-triazole (13–24) on results assays was evaluated.